The illustration of the viral membrane lipid bi-layer shows the water-loving heads (yellow circles) and water-hating tails (blue squiggles). AEG12, based on the protein’s crystal structure (green and gray), inserts some of its lipids (green squiggles) into the viral membrane, destabilizing it. During this exchange, AEG12 incorporates viral lipids into its interior (blue and gray). …